Clinical and pathological features of idiopathic membranous nephropathy patients combined with hyperuricemia

Clinical and pathological features of idiopathic membranous nephropathy patients combined with hyperuricemia

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Objective To investigate the clinical and pathological features of idiopathic membranous nephropathy( IMN) patients combined with hyperuricemia.Methods A retrospective analysis was conducted by collecting 125 cases of IMN diagnosed by renal biopsy in our hospital between January 2014 and January 2017.According to the serum uric acid level,the enrolled patients were further divided into two groups: normal serum uric acid group( n = 77) and hyperuricemia group( n = 48),and the clinical data and pathological features of the two groups were compared subsequently.Results In the 125 patients with IMN,the serum creatinine and blood urea nitrogen levels were significantly higher and the estimated glomerular deus gorras filtration rate was significantly lower in the hyperuricemia group than those in the normal serum uric acid group( P 0.

05 for all).Renal tissue examination results under light microscope suggested that glomerulus sclerosis,segmental glomerulosclerosis,tubular atrophy/interstitial fibrosis ratio were significantly increased in the hyperuricemia group than those in the normal serum uric acid group( P 0.05).In the hyperuricemia group,the proportion of dense deposits in the mesangial region was higher than that in the normal serum uric acid group under electron microscopy( P 0.

05).Conclusions IMN patients with hyperuricemia show marked changes in glomerular and tubulointerstitial diseases,and hyperuricemia may be an important factor in the progression voyage et cie discount code of IMN.